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Reference type: Journal
Authors: Jing T, Gao XD, Wang P, Wang Y, Lin YF, Hu XZ, Hao QL, Zhou YK, Mei SR
Article Title: Determination of trace tetracycline antibiotics in foodstuffs by liquid chromatography–tandem mass spectrometry coupled with selective molecular-imprinted solid-phase extraction.
Publication date: 2009
Journal: Analytical and Bioanalytical Chemistry
Volume: 393
Issue: (8)
Page numbers: 2009-2018.
DOI: 10.1007/s00216-009-2641-z

Abstract: Abstract A rapid, specific, and sensitive method has been developed using molecularly imprinted polymers (MIPs) as solid-phase extraction sorbents for extraction of trace tetracycline antibiotics (TCs) in foodstuffs. MIPs were prepared by precipitation polymerization using tetracycline as the template. Under the optimal condition, the imprinting factors for MIPs were 4.1 (oxytetracycline), 7.0 (tetracycline), 7.4 (chlortetracycline), 7.7 (doxycycline), respectively. Furthermore, the performance of MIPs as solid-phase extraction sorbents was evaluated and high extraction efficiency of molecularly imprinted solid-phase extraction (MISPE) procedure was demonstrated. Compared with commercial sorbents, MISPE gave a better cleanup efficiency than C18 cartridge and a higher recovery than Oasis HLB cartridge. Finally, the method of liquid chromatography–tandem mass spectrometry coupled with molecular-imprinted solid-phase extraction was validated in real samples including lobster, duck, honey, and egg. The spiked recoveries of TCs ranged from 94.51% to 103.0%. The limits of detection were in the range of 0.1–0.3 ?g kg?1
Template and target information: oxytetracycline, tetracycline, chlortetracycline, doxycycline
Author keywords: Tetracycline antibiotics, precipitation polymerization, molecularly imprinted solid-phase extraction, Foodstuff, Liquid chromatography–tandem mass spectrometry


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