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Reference type: Journal
Authors: Prasad BB, Srivastava S, Tiwari K, Sharma PS
Article Title: Ascorbic acid sensor based on molecularly imprinted polymer-modified hanging mercury drop electrode.
Publication date: 2009
Journal: Materials Science and Engineering: C
Volume: 29
Issue: (4)
Page numbers: 1082-1087.
DOI: 10.1016/j.msec.2008.09.025
Alternative URL: http://www.sciencedirect.com/science/article/B6TXG-4THC1C1-4/2/444faf4f5927a695d3ae7650cc226c04

Abstract: Ascorbic acid sensor based on molecularly imprinted polymer (MIP) is reported for sensitive and selective analysis, without any cross-reactivity or matrix effect, in aqueous, blood serum and pharmaceutical samples. The sensor was developed by the direct coating of ascorbic acid-imprinted polymer, prepared from melamine and chloranil, on the surface of a hanging mercury drop electrode (HMDE) at +0.4V (vs. Ag/AgCl). The molecular recognition of ascorbic acid was highly specific using non-covalent (hydrophobically driven hydrogen-bonding and electrostatic) interactions. The analyte was preconcentrated and oxidised instantaneously in the imprinted polymer layer giving voltammetric signal on cathodic stripping at optimised operational conditions: accumulation potential +0.4V (vs. Ag/AgCl), polymer deposition time 120s, template accumulation time 120s, pH 7.0, scan rate 10mV s-1, pulse amplitude 25mV. The proposed MIP sensor is able to enhance sensitivity substantially so as to detect serum ascorbic acid level as low as 0.26ng mL-1 (R.S.D. 0.5%, S/N 3) for the diagnosis of hypovitaminosis C (Vitamin C deficiency)
Template and target information: ascorbic acid, vitamin C
Author keywords: voltammetric sensor, ascorbic acid, Molecularly imprinted polymerisation, differential pulse, Cathodic stripping voltammetry


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