MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Khasawneh MA, Vallano PT, Remcho VT
Article Title: Affinity screening by packed capillary high performance liquid chromatography using molecular imprinted sorbents II. Covalent imprinted polymers.
Publication date: 2001
Journal: Journal of Chromatography A
Volume: 922
Issue: (1-2)
Page numbers: 87-97.
DOI: 10.1016/S0021-9673(01)00932-3

Abstract: This study concentrates on the production of covalent molecular imprint polymers (MIPs) as highly selective sorbents for nortriptyline (NOR), a representative tricyclic antidepressant (TCA). The functionalized template contains a polymerizable 4- vinylphenyl carbamate moiety used to bind the template molecule to the polymer matrix. Polymerization with a cross-linker followed by hydrolytic cleavage of the labile carbamate functionality leaves an MIP with selective binding sites capable of binding template through hydrogen bonding interactions. Demonstrated chromatographically through a "selection index", these MIPs showed high selectivity for the template molecule (NOR) among a library of structurally similar compounds. The recognition was found to correlate with structural similarity to the template compound. A direct comparison between covalent and non-covalent molecular imprinting strategies reveals a great deal of improvement in the peak shape of the retained compound resulting from covalent imprinting (evidenced by peak asymmetry factors A(s)). (C) 2001 Elsevier Science B.V. All rights reserved


  mipdatabase.com logo special offer joke shirt  Lab Rat Periodic table bag  HE-MAN polymer chemistry shirt

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner