Alternatively for mipdatabase quick searches go here

Custom Search

Abstract: The immobilization methods of biomolecules into nanostructured polypyrroles, namely, adsorption, entrapment during the electropolymerization process, covalent binding, and molecular imprint are systematically summarized based on the latest literatures. The operational principle and detective capacities of the nanostructured polypyrroles-based amperometric biosensors such as enzyme biosensor, nucleic acid biosensor, and immunosensor are also highly reviewed. It is pointed out that the nanostructured polypyrroles with excellent biocompatibility, selective permeability, interference immunity, and large specific surface area significantly favor enhancing loading capacity and keeping bioactivity of biomoleculs, resulting in higher sensitivity, selectivity, and environmental stability biosensors. Composite of polypyrrole and some metal nanoparticles or carbon nanotubes exhibits synergistic effect and remarkably enhances sensitivity in current. After nanosturctrued polypyrroles decorated, the electrocatalytic activity and detection limit of electrode are improved by 2 -4 orders and 5.0 x 10(4) times, respectively. Biosensors based on nanostructured polypyrroles have shown great potential applications in the biomedicine, clinical diagnosis, environmental monitoring, and food analysis
Author keywords: polypyrrole, Nanostructure, biomolecule immobilization, biosensor, review