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Reference type: Journal
Authors: Roche PJR, Ng SM, Narayanaswamy R, Goddard N, Page KM
Article Title: Multiple surface plasmon resonance quantification of dextromethorphan using a molecularly imprinted β-cyclodextrin polymer: A potential probe for drug-drug interactions.
Publication date: 2009
Journal: Sensors and Actuators B: Chemical
Volume: 139
Issue: (1)
Page numbers: 22-29.
DOI: 10.1016/j.snb.2008.07.029
Alternative URL: http://www.sciencedirect.com/science/article/B6THH-4T8JXCK-1/2/e9f16a5d50e6df5f0689c5daf519487d

Abstract: A surface plasmon resonance sensor for the detection of the common cough suppressant, dextromethorphan is demonstrated. Dextromethorphan is a pharmacological important marker drug used to identify the activity of the CYP2D6 class of p450 monoxygenases. Detection and quantification is achieved by measuring the refractive index changes of multiple surface plasmons resulting from the binding to template pockets within the thin layer imprinted β-cyclodextrin polymer. Initial investigations of the molecular imprinted polymer were conducted using reflectance spectroscopy. A detection limit of 0.035μM and a dynamic range of 0.035μM to 6.00mM dependent upon instrumental setup have been demonstrated and the data are comparable with liquid chromatography-mass spectroscopy and commercial fluorescence based methodologies. The sensor could potentially be used to measure the consumption of dextromethorphan by CYP enzymes
Template and target information: dextromethorphan
Author keywords: surface plasmon resonance, molecularly imprinted polymer, Dextromethorphan, β-cyclodextrin, Drug interaction


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