Abstract: Long open tubular S-ketoprofen molecule imprinted polymer capillary columns (1, 2, and 3 m) with the number of theoretical plates (N) over a million for both chrial and non-chiral CEC separation have been prepared. Chiral separation of racemic ketoprofen and non-chiral separation of other profen drugs have been achieved with excellent efficiency and good selectivity after optimization of the chromatographic conditions. The N value per column was not proportional to the effective column length although it was increased with the column length. This study has shown the outstanding prospect of the strategy to form a porous and rugged open tubular layer in a moderately long (1 m) capillary column in molecule imprinted polymer-CEC studies
Template and target information: S-ketoprofen
Author keywords: Excellent separation efficiency, Long column, Open tubular-CEC, S-Ketoprofen molecule imprinted polymer