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Abstract: A restricted access media-molecularly imprinted polymer (RAM-MIP) for cyclobarbital has been developed for selective extraction of antiepileptics in river water samples. The RAM-MIP was prepared using 4-vinylpyridine and ethylene glycol dimethacrylate as a functional monomer and cross-linker, respectively, by a multi-step swelling and polymerization method followed by a surface modification technique. The RAM-MIP for cyclobarbital showed molecular recognition abilities for phenobarbital, amobarbital and phenytoin as well as cyclobarbital. Thus, selective analysis of antiepileptics in river water samples was attained with RAM-MIP extraction followed by column-switching liquid chromatography-tandem mass spectrometry. The concentrations of phenobarbital and phenytoin in river water samples were about 15 and 4áng/L, respectively, while that of amobarbital was below the limit of quantitation
Template and target information: antiepileptics, cyclobarbital, phenobarbital, amobarbital, phenytoin
Author keywords: Restricted access media, molecularly imprinted polymer, sample preparation, Liquid chromatography-tandem mass spectrometry, environmental analysis, Cyclobarbital, phenobarbital, Amobarbital, phenytoin