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Reference type: Journal
Authors: Sun XL, He XW, Zhang YK, Chen LX
Article Title: Determination of tetracyclines in food samples by molecularly imprinted monolithic column coupling with high performance liquid chromatography.
Publication date: 2009
Journal: Talanta
Volume: 79
Issue: (3)
Page numbers: 926-934.
DOI: 10.1016/j.talanta.2009.05.033
Alternative URL: http://www.sciencedirect.com/science/article/B6THP-4WCTWM3-1/2/915afadcb8530911fc3328ce1c4e02e7

Abstract: A novel solid phase extraction (SPE) method for determination of tetracyclines (TCs) in milk and honey samples by molecularly imprinted monolithic column was developed. Using tetracycline (TC) as the template, methacrylic acid (MAA) as the functional monomer, ethylene glycol dimethacrylate (EGDMA) as the cross-linker, methanol as the solvent, cyclohexanol and dodecanol as the mixed porogenic solvents, a TC imprinted monolithic column was prepared by in situ molecular imprinting technique for the first time, and the optimal synthesis conditions and the selectivity of TC imprinted monolithic column were investigated. The interfering substances in food samples and TCs can be separated successfully on imprinted column. Molecularly imprinted solid phase extraction (MISPE) coupling with C18 column was used to determinate the TCs in milk and honey. The recoveries of this method for six tetracyclines antibiotics such as tetracycline (TC), oxytetracycline (OTC), minocycline (MINO), chlortetracycline (CTC), metacycline (MTC) and doxycycline (DTC) were investigated, and high recoveries of 73.3-90.6% from milk samples and 62.6-82.3% from honey samples were obtained. A method for determination of TCs at low concentration level in milk and honey samples was successfully developed by using the monolithic column as the precolumn for solid phase extraction of six TCs compounds
Template and target information: tetracycline, TC, oxytetracycline, OTC, minocycline, MINO, chlortetracycline, CTC, metacycline, MTC, doxycycline, DTC
Author keywords: Molecularly imprinted solid phase extraction (MISPE), In situ polymerization, molecularly imprinted monolithic column, Tetracyclines, determination

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