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Reference type: Journal
Authors: Freitas MB, Costa PR, Brito JO, Vieira EP, Maia PP, Siqueira MEPB
Article Title: Amitriptyline and Nortriptyline in Plasma: Solid-Phase Extraction in Molecularly Imprinted Polymers and Silica Octadecil for High Performance Liquid Chromatography Analysis.
Publication date: 2009
Journal: Latin American Journal of Pharmacy
Volume: 28
Issue: (1)
Page numbers: 70-79.
Alternative URL: http://www.latamjpharm.org/trabajos/28/1/LAJOP_28_1_1_10_BSW1ZD0431.pdf

Abstract: The ormosils (silica organically modified) are molecularly imprinted materials (MIS) that have appeared as new selective sorbents for solid-phase extraction (SPE). This research aimed the evaluation of the performance of MIS in SPE (MISPE) and of the silica octadecil (C18) SPE in the sample preparation for liquid chromatographic analysis of amitriptyline (AMI) and nortriptyline (NOR) in plasma. The optimization of the SPE variables were established and the analysis were performed using a HPLC system with UV detection. Under the conditions used for the synthesis of MIS and its application in MISPE, there was no satisfactory response in the chromatographic analysis of the antidepressants, mainly due to the low repeatability of the results in the concentration range of concern. For AMI and NOR, the extraction using SPE C18 offered better results and this method was validated and applied to the analysis of real samples of plasma from two patients under AMI treatment
Template and target information: amitriptyline, nortriptyline, AMI, NOR
Author keywords: Amitriptyline, HPLC, molecularly imprinted polymer, nortriptyline, sample preparation, SPE

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