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Reference type: Journal
Authors: Ceolin G, Navarro-Villoslada F, Moreno-Bondi MC, Horvai G, Horvath V
Article Title: Accelerated Development Procedure for Molecularly Imprinted Polymers Using Membrane Filterplates.
Publication date: 2009
Journal: Journal of Combinatorial Chemistry
Volume: 11
Issue: (4)
Page numbers: 645-652.
DOI: 10.1021/cc900022u

Abstract: A novel technique for the synthesis and testing of large numbers of molecularly imprinted polymers is described requiring much less time than the commonly used miniMIP approach. Instead of vials, the polymers are synthesized on the surface of microfiltration membranes in multiwell filterplates. The thin polymeric films enable accelerated template removal. The MIP development procedure is thereby shortened to two days. Performance of the system was demonstrated by creating a combinatorial library of MIPs selective for cimetidine, an antiulcer drug. The polymer composition has been optimized. An experimental design combined with a multivariate analysis (i.e., response surface modeling) was used to minimize the number of experiments in the optimization process. The highest imprinting factor was obtained using a MAA/EDMA/template molar ratio of 3.5:19.5:1
Template and target information: cimetidine

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