MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Lv RH, Xu L, Huang XH, Wang YQ, Zhang J
Article Title: Preparation and evaluation of a molecularly imprinted polymer for tolazoline.
Publication date: 2010
Journal: Journal of Applied Polymer Science
Volume: 115
Issue: (1)
Page numbers: 198-203.
DOI: 10.1002/app.31037

Abstract: A uniformly sized molecularly imprinted polymer for the peripheral vasodilator drug tolazoline (T-MIP) was prepared, and a nonimprinted polymer (NIP) was also synthesized in the same way but in the absence of the template. The T-MIP was prepared with methylacrylic acid as functional monomer and ethylene glycol dimethacrylate as crosslinker by a multistep swelling and polymerization method. These imprinted materials were characterized by scanning electron microscopy, nitrogen adsorption, and static adsorption experiments. Binding studies were also performed to evaluate the uptake of T-MIP and NIP with the results that T-MIP had a significantly higher binding capacity for tolazoline (T) than did NIP. The maximum static adsorption capacities of T-MIP and NIP for T were 78.9 and 38.8 mumol/g, respectively. The T-MIPs and NIPs were used as stationary phases of solid-phase extraction (SPE), and a relative selectivity coefficient (kprime) value of 5.21 was obtained, which showed that the T-MIP sorbent had higher selectivity than the NIP sorbent. The method was applied to the determination of T in urine samples. The prepared polymer sorbent showed promise for SPE for gas chromatography determination of T in urine samples. 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Template and target information: tolazoline
Author keywords: molecular imprinting, polystyrene, step-growth polymerization


  SMI logo travel mug  Mother Periodic table shirt  Lab Chick script shirt

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner