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Reference type: Journal
Authors: Gholivand MB, Khodadadian M, Ahmadi F
Article Title: Computer aided-molecular design and synthesis of a high selective molecularly imprinted polymer for solid-phase extraction of furosemide from human plasma.
Publication date: 2010
Journal: Analytica Chimica Acta
Volume: 658
Issue: (2)
Page numbers: 225-232.
DOI: 10.1016/j.aca.2009.11.019
Alternative URL: http://www.sciencedirect.com/science/article/B6TF4-4XPP12W-6/2/1af3a2515d617f415231d6f60dc839a8

Abstract: Highly selective molecularly imprinted polymers (MIPs) for solid-phase extraction and determination of furosemide in human plasma have been designed and prepared. In order to study the intermolecular interactions in the pre-polymerization mixture and to find a suitable functional monomer in MIP preparation, a computational approach was developed. It was based on the comparison of the binding energy of the complexes between the template and functional monomers. Having confirmed the results of computational method, three MIPs were synthesized with different functional monomers, i.e. acrylamide (AAM), 4-vinylpiridine (4-VP) and acrylonitrile (ACN), and then evaluated using Langmuir-Freundlich (LF) isotherm. Using the MIP prepared by AAM as functional monomer, a molecularly imprinted solid-phase extraction procedure followed by high performance liquid chromatography with ultraviolet detector (MISPE-HPLC-UV) was developed for selective extraction and determination of furosemide in human plasma. For the proposed MISPE-HPLC-UV method, the linearity between responses (peak area) and concentration was found over the range of 75-3500ángámL-1 with a linear regression coefficient (R2) of 0.997. The limit of detection (LOD) and quantification (LOQ) in plasma were 12.9 and 43.3ángámL-1, respectively
Template and target information: furosemide
Author keywords: molecular imprinted polymer (MIP), Ab initio calculation, Furosemide, separation


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