Abstract: A novel electrochemical sensor for the detection of tolazoline based on molecularly imprinted polymer of electropolymerized o-aminothiophenol onto a gold electrode was constructed. Its response to to-lazoline was evaluated by differential pulse voltammmograms (DPV). Under the optimized conditions, the response current of the proposed sensor decreased linearly in two concentration ranges of tolazoline from 0.4 to 5 mu g.mL(-1) (r=0.9986) and from 5 to 120 mu g.mL(-1) (r=0.9953) with a detection limit of 0.18 mu g.mL(-1). The RSD (relative standard deviation) was about 2.47% and the response time was closed to 3 min. Moreover, the studied imprinted sensor exhibited high selectivity and long-term stability, and was successfully applied to the determination of tolazoline in human urine samples
Template and target information: tolazoline
Author keywords: Electrochemical sensor, molecular imprinting technique, electropolymerization film, tolazoline