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Abstract: A PVC membrane based on metoprolol molecularly imprinted polymer (MIP) coated directly on graphite electrode for determination of metoprolol in real sample is described. This potentiometric sensor was designed by dispersing the MIP particles in dioctylphthalate plasticizer as solvent mediator and then embedded in polyvinyl chloride matrix. The electrode exhibits a near Nernstian of 55.4 +/- 1 mV decade(-1) for metoprolol over a wide concentration range between 2.0 x 10(-7)-8.0x10(-3) M and a detection limit of 1.26 x 10(-7) M. It has a response time of about 14 seconds and can be used for at least 6 months without any divergence in potential. The proposed electrode can be used in the pH range of 3.5-10.5 and revealed good selectivities for metoprolol over a wide variety of ions. Finally, the designed sensor was successfully applied as an indicator electrode to determine concentration of metoprolol in tablets, human urine and plasma and the results were compared favorably with those obtained by HPLC method and showed satisfactory agreements with them
Template and target information: metoprolol
Author keywords: Metoprolol, Ion-selective electrode, molecularly imprinted polymer, PVC-membrane, Coated graphite