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Reference type: Journal
Authors: Prasad BB, Madhuri R, Tiwari MP, Sharma PS
Article Title: Imprinted polymer-carbon consolidated composite fiber sensor for substrate-selective electrochemical sensing of folic acid.
Publication date: 2010
Journal: Biosensors and Bioelectronics
Volume: 25
Issue: (9)
Page numbers: 2140-2148.
DOI: 10.1016/j.bios.2010.02.016
Alternative URL: http://www.sciencedirect.com/science/article/B6TFC-4YG7JT2-4/2/21760a778f55cba031f13a6b902f6b3a

Abstract: Molecularly imprinted polymers (MIPs) are often electrically insulating materials. Due to the presence of diffusion barrier(s) in between such MIP coating and electrode surface and the absence of a direct path for the conduction of electrons from the binding sites to the electrode, the development of electrochemical sensor is significantly restricted. The direct use of MIPs those possess intrinsic electron-transport properties, is highly limited. These problems are resolved by the design of an original, substrate-selective MIP-fiber sensor that combines conventional insulating MIP and conducting carbon powder in consolidated phase. A layer of conducting carbon particles, arranged orderly as 'carbon strip', is inducted in the polymer for direct electronic conduction. MIP-carbon composite (monolithic fiber) in this work is prepared via in situ free radical polymerization of a new monomer (2,4,6-trisacrylamido-1,3,5-triazine, TAT) and subsequent cross-linkage with ethylene glycol dimethacrylate, in the presence of carbon powder and template (folic acid), at 55 C in a glass capillary. The detection of folic acid with the MIP-fiber sensor was found to be specific and quantitative (detection limit 0.20 ng mL-1, RSD = 1.3%, S/N = 3), in aqueous, blood serum and pharmaceutical samples, without any problem of non-specific false-positive contribution and cross-reactivity
Template and target information: folic acid
Author keywords: Molecularly imprinted polymer-carbon composite, Folic acid, Salt-bridge association, MIP-fiber sensor, differential pulse, Cathodic stripping voltammetry


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