Paper 5734

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Reference type: Journal
Authors: Lalo H, Ayela C, Dague E, Vieu C, Haupt K
Article Title: Nanopatterning molecularly imprinted polymers by soft lithography: a hierarchical approach.
Publication date: 2010
Journal: Lab on a Chip
Volume: 10
Issue: (9)
Page numbers: 1316-1318.
DOI: 10.1039/b924315a

Abstract: We use soft lithography to pattern molecularly imprinted polymers (MIPs) at the nanoscale. Patterning occurs via a micro transfer molding process associated with an edge effect. We show using fluorescence microscopy that the nanopatterned synthetic receptors specifically recognize and bind a model target, dansyl-L-phenylalanine. We also demonstrate using AFM a specific swelling of the MIP pattern in the presence of the analyte. We believe that this opens new opportunities for the application of MIPs in microsensors and microbiochips, for example in environmental analysis and biomedical diagnostics.
Template and target information: dansyl-L-phenylalanine

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