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Abstract: A series of molecularly imprinted polymeric microspheres (MIPMs) with different structures were prepared via a single-step swelling and polymerization method with caffeine as template molecules. The relationships between structure and adsorption and recognition capabilities of the MIPMs were then investigated. The results indicate that the adsorption and recognition capabilities of the MIPMs for the template molecules can be enhanced by enlarging their specific surface area, increasing their swelling ratio or their density of binding sites within a certain range, since those means increase the number of accessible binding sites of the MIPMs. It was also found that, increasing the stiffness of the MIPMs, the stabilities of imprinted cavities may be enhanced, thereby enhances the recognition capabilities of the MIPMs for the template molecules, but weakens the adsorption capabilities of the MIPMs at the same time. Moreover, the adsorption and recognition capabilities of different binding sites of the MIPMs were analyzed from the perspective of thermodynamics. The results show that the adsorption and recognition capabilities of the binding sites with high affinity are much better than that of the binding sites with low affinity
Template and target information: caffeine
Author keywords: molecular imprinting, molecularly imprinted polymeric microspheres, Property thermodynamics, Structure