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Abstract: The orbicular molecularly imprinted polymer (OC-MIP) was prepared by two steps including the precipitation polymerization and the opening the GMA epoxide ring. Then the hydrophilic external layer on the surface of OC-MIP was formed. The OC-MIP was characterized by infrared spectra and scanning electron microscopy (SEM). Water absorption measurement showed the OC-MIP had stronger water compatible than MIP. When the proportion of MAA/GMA was 1:1, and DVB is 3 times of MAA co GMA, the particle shapes of MIPs were uniform and the recognition and release of OC-MIP in polar solvent were satisfactory. The results showed GMA added in the polymers could adjust the capability of release of the polymers certainly. After the GMA epoxide ring was opened, OC-MIP synthesized was more suitable to be employed in biological media because of the reduction of non-specific hydrophobic interactions. In addition, the polymers had the capability of recognition, also could satisfy the study of both drug recognition and sustained-release in polar solvent
Template and target information: S-naproxen
Author keywords: Molecularly imprinted polymers, precipitation polymerization, Recognition and release, S-naproxen