MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Moreira FTC, Kamel AH, Guerreiro JRL, Sales MG
Article Title: Man-tailored biomimetic sensor of molecularly imprinted materials for the potentiometric measurement of oxytetracycline.
Publication date: 2010
Journal: Biosensors and Bioelectronics
Volume: 26
Issue: (2)
Page numbers: 566-574.
DOI: 10.1016/j.bios.2010.07.036
Alternative URL: http://www.sciencedirect.com/science/article/B6TFC-50JPN7R-1/2/e279753a82d2a38299dda7712b414aba

Abstract: A novel biomimetic sensor for the potentiometric transduction of oxytetracycline is presented. The artificial host was imprinted in methacrylic acid and/or acrylamide based polymers. Different amounts of molecularly imprinted and non-imprinted polymers were dispersed in different plasticizing solvents and entrapped in a poly(vinyl chloride) matrix. Only molecularly imprinted based sensors allowed a potentiometric transduction, suggesting the existence of host-guest interactions. These sensors exhibited a near-Nernstian response in steady state evaluations; slopes and detection limits ranged 42-63 mV/decade and 2.5-31.3 μg/mL, respectively. Sensors were independent from the pH of test solutions within 2-5. Good selectivity was observed towards glycine, ciprofloxacin, creatinine, acid nalidixic, sulfadiazine, cysteine, hydroxylamine and lactose. In flowing media, the biomimetic sensors presented good reproducibility (RSD of 0.7%), fast response, good sensitivity (65 mV/decade), wide linear range (5.0 x 10-5 to 1.0 x 10-2 mol/L), low detection limit (19.8 μg/mL), and a stable baseline for a 5 x 10-3 M citrate buffer (pH 2.5) carrier. The sensors were successfully applied to the analysis of drugs and urine. This work confirms the possibility of using molecularly imprinted polymers as ionophores for organic ion recognition in potentiometric transduction
Template and target information: oxytetracycline
Author keywords: Molecularly imprinted sensors, Potentiometry, ion-selective electrodes, oxytetracycline, flow-injection analysis


  Mug featuring the name Felismina spelled out in symbols of the chemical elements  Chemistry peptide mug  Beach bunny periodic table shirt

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner