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Abstract: Molecular imprinting technology is a borderline subject newly developed from combining high polymer chemistry, biochemistry, etc. Molecularly imprinted polymer prepared by molecular imprinting technology is a new polymer material with many advantages, such as excellent selectivity, high adsorption, high efficiency in chromatography and easy design. It is being increasingly used for several high technology fields, for instance, solid-phase extraction, chromatographic separation, bio- and chemo-sensors, targeted drug delivery, catalysis, immunoassays and artificial enzyme, etc. As a kind of novel functional materials, magnetic polymer microspheres developed in recent years have been widely used in the collection or separation of bioactive substances, targeted drug delivery, and disease's diagnoses or therapy. The core-shell magnetic molecular imprinted polymer microspheres prepared by surface molecularly imprinting on magnetism particles have combined the advantages of both molecularly imprinted polymer and magnetic polymer microspheres, especially good superparamagnetism and high selective adsorption. This review focuses on the preparation, structure and properties of core-shell magnetic molecularly imprinted polymer microspheres, as well as their application in chemical analysis, biological separation, and targeted drug delivery in recent years. The problems and challenges that still should be resolved are pointed out and the development tendency in these researches is discussed
Template and target information: Review - MIPs magnetic core-shell particles
Author keywords: molecular imprinting, core-shell magnetic molecularly imprinted polymer microspheres, Preparation, application