MIPdatabase
Authors: Cizmárik A, Lachová M, Lehotay J, Skacáni I
Article Title: Studies of local anesthetics. Part: 187 Extraction of 1-methyl-2- piperidinoethylesters of alkoxyphenylcarbamic acids from human plasma by imprinted polymers and its comparison with classic solid phase extraction.
Publication date: 2009
Journal: Ceska a Slovenska Farmacie
Volume: 58
Issue: (2)
Page numbers: 78-82.
Abstract: Molecularly imprinted polymers for 1-methyl-2-piperidinoethylester of 2-methoxyphenylcarbamic acid (template) have been synthesised. Acrylamide and methacrylic acids, respectively, were used as the functional monomers. Imprinted polymers were used as the sorbents for solid-phase extraction (MISPE). The capacity and selectivity of prepared imprinted polymers were investigated with the use of some derivatives of 1-methyl-2-piperidinethylesters of alkoxyphenylcarbamic acids. The non-imprinted (blank) polymers were prepared by the same way without a template to study the non-specific interactions. The molecularly imprinted polymer prepared from methacrylic acid was used to preconcentrate 1-methyl-2-piperidinoethylester of 2-methoxyphenylcarbamic acid and its analogues from spiked human plasma (1 μg in 1 ml of plasma)
Template and target information: 1-methyl-2-piperidinoethylester of 2-methoxyphenylcarbamic acid
Author keywords: Esters of alkoxyphenylcarbamic acids, HPLC, imprinted polymers, solid phase extraction
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