MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Nicholls IA, Karlsson BCG, Rosengren AM, Henschel H
Article Title: Warfarin: an environment-dependent switchable molecular probe.
Publication date: 2010
Journal: Journal of Molecular Recognition
Volume: 23
Issue: (6)
Page numbers: 604-608.
DOI: 10.1002/jmr.1058

Abstract: Abstract: The complex nature of the structure of the anticoagulant warfarin is reflected in the diversity of binding modes observed in warfarin - protein recognition systems. A series of theoretical, 1H-NMR and steady state and time resolved fluorescence spectroscopic studies, have been used to establish correlations between the molecular environment provided by various solvent systems and the relative concentrations of the various members of warfarin's ensemble of isomers. A consequence of these observations is that the judicious choice of solvent system or molecular environment of warfarin allows for manipulation of the position of the equilibrium between isomeric structures such as the hemiacetal and open phenol-keto forms, the latter even possible in a deprotonated form, where in each case unique spectroscopic properties are exhibited by the respective structures. Collectively, warfarin's capacity to adapt its structure as a function of environment in conjunction with the fluorescence behaviours of the various isomers together provide an environment-dependent molecular switch with reporter properties, which allows for the simultaneous detection of warfarin in different states with lifetimes spanning the range < 0.10 - 5.5 ns. These characteristics are here used to examine warfarin binding domains in a series of materials (solvents, protein, inorganic matrix and synthetic polymer). Moreover, these studies demonstrate the potential for using warfarin, or other switchable analogues thereof, as a tool for studying molecular level characteristics, for example local dielectricity. Copyright 2010 John Wiley & Sons, Ltd
Template and target information: warfarin
Author keywords: Warfarin, fluorescence, fluorescence lifetimes, organic solvents, molecular recognition, molecular probe, molecularly imprinted polymer, human serum albumin, HSA, colloidal silica, TCSPC


  Mister Benzene Comic Strip greetings card  Mug featuring the name Ian spelled out in the single letter amino acid code  Beach bunny periodic table shirt

Molecules Special Issue call      Appeal for information






Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:
US listings   UK listings

Searching for Molecular Imprinting books on Amazon.com:
Molecular Imprinting
Imprinted Polymers
Polymer Chemistry
Organic Chemistry
Biosensors

Find what you need at Amazon.com

Lab supplies from Amazon