MIPdatabase
Authors: Cirillo G, Curcio M, Parisi OI, Puoci F, Iemma F, Spizzirri UG, Restuccia D, Picci N
Article Title: Molecularly imprinted polymers for the selective extraction of glycyrrhizic acid from liquorice roots.
Publication date: 2011
Journal: Food Chemistry
Volume: 125
Issue: (3)
Page numbers: 1058-1063.
DOI: 10.1016/j.foodchem.2010.09.077
Alternative URL: http://www.sciencedirect.com/science/article/B6T6R-51336DH-5/2/2eeb9998040a179c3847aff8234a34d6
Abstract: A new Molecularly Imprinted Solid Phase Extraction (MISPE) protocol was developed for the selective extraction and purification of glycyrrhizic acid (GL) from liquorice roots. Non-covalent MIP were synthesized using methacrylic acid (MAA), 2-(dimethylamino)ethyl methacrilate (DMAEM) or 2-hydroxyethylmetacrylate (HEMA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as crosslinking agent. After the evaluation of the selectivity of the GL imprinted polymers, the performance of these materials as Solid Phase Extraction (SPE) sorbents was investigated. MIP having HEMA as functional monomer were found to be able to selectively extract almost 80% of GL content in liquorice roots. The proposed MISPE-HPLC procedure has good precision, thus it can be successfully used for the purification of GL from natural sources
Template and target information: glycyrrhizic acid, GL
Author keywords: Molecularly imprinted polymers, glycyrrhizic acid, solid phase extraction, Liquorice roots
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