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Publisher: Nanoscience and Technology Institute
Volume number: 3
Conference information: Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010

Abstract: Living systems communicate by molecular recognition. This central principle of the living world is performed at the contact sites of different objects such as single macromolecules or highly complex supramolecular assemblies as which living cells may be described. Molecular recognition capabilities are evoked at artificial materials by the NANOCYTES-technology of the Fraunhofer IGB and biomimetic nanoparticles are synthesized that possess molecularly recognizing properties. NANOCYTES carry molecularly defined binding sites at their surface. These binding sites are either composed from biologically derived macromolecules or fully synthetic receptors. Core-shell nanoparticles are particularly suited for this purpose, e.g. to immobilise a specific protein or a protein complex at their shell surface. Entirely synthetic molecularly recognising nanoparticles can also be prepared by chemical nanotechnology. A cooperative chemical reaction evokes the formation of specific molecular binding sites at the surface of copolymer nanoparticles. Such synthetic receptors may be employed e.g. as specific absorbers to remove micropollutants from the drinking water cycle or as functional unit of a biosensor. The talk will highlight the design and application of biomimetic nanoparticles based on the structural concepts described above
Author keywords: biomimetics, Core-shell nanoparticles, Specific absorbers, synthetic receptors