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Reference type: Journal
Authors: Shimizu KD, Stephenson CJ
Article Title: Molecularly imprinted polymer sensor arrays.
Publication date: 2010
Journal: Current Opinion in Chemical Biology
Volume: 14
Issue: (6)
Page numbers: 743-750.
DOI: 10.1016/j.cbpa.2010.07.007
Alternative URL: http://www.sciencedirect.com/science/article/B6VRX-50P449B-1/2/198b48996efe22dd8f548aa3994f88fc

Abstract: The sensor array format has proved an effective method of transforming sensors of modest selectivity into highly selective and discriminating sensors. The primary challenge in developing new sensor arrays is collecting together a sufficient number of recognition elements that possess different binding affinities for the analytes of interest. In this regard, the use of molecularly imprinted polymers (MIPs) as the recognition elements in sensor arrays has a number of unique advantages. MIPs can be rapidly and inexpensively prepared with different selectivities and tuned with different selectivity patterns via the choice of templates in the imprinting process. The array format also helps compensate for the low selectivities and high cross-reactivities of MIP sensors. These attractive qualities of MIP sensor arrays have been demonstrated in recent examples, which have established the viability and generality of the approach. In particular, the versatility of the imprinting process enables MIP sensor arrays to be tailored to specific analytes. MIP sensor arrays have also shown surprisingly broad utility, as even analytes that were not used as templates in the imprinting process can be effectively discriminated
Template and target information: Review - MIPs in sensor arrays


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