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Abstract: A molecularly imprinted polymers (MIPs) was synthesized by using ethyl paraben (EP) as template and methacrylic acid as functional monomer, and a molecularly imprinted electrode was constructed on the surface of a glassy carbon electrode for determination of parabens, such as EP, methyl paraben (MP), butyl paraben (BP) and propyl paraben (PP). Electrochemical oxidation behaviors of EP on the imprinted electrode were investigated by square wave voltammetric method. When using the incubation time of 15 min, the peak currents at oxidation potential of 0.95 V(vs SCE) were proportional to the concentration of EP in the range of 2.0 × 10-6 to 2.0 × 10-4 mol/L with a detection limit of 1.0 μmol/L (S/N = 3). The RSD (n = 10) of the imprinted electrode for peak current was 4.3% (n = 10). Under the same conditions, the extremely small responses of the control electrode were observed and independent of the analyte concentration. The oxidation potential of EP recorded with imprinted electrode was a slight positive shift comparing with that of the bare electrode. The imprinted electrode also displayed good specific binding MP, PP and BP, and their selective coefficients of imprinted electrode were 1.89, 1.70 and 2.01, respectively. Structural analogs, such as phenol, p-hydroxybenzoic acid and p-aminobenzoic acid, only small responses electrode were observed. Moreover, structural unanalog vitamin C had almost no response. The imprinted electrode was used for analysis of parabens in actual samples with the spiked recoveries more than 90%. The molecularly imprinted polymer electrode showed good sensitivity and selectivity, and was simple to construct and operate. (Analytical Abstracts 2010)
Template and target information: ethyl paraben, EP, methyl paraben, MP, butyl paraben, BP, propyl paraben, PP
Author keywords: Molecularly imprinted polymer membrane, paraben, Square wave voltammetry, Electrochemical sensor