Authors: Haginaka J
, Sakai Y
, Narimatsu S
Preparation of molecularly imprinted polymers for propanolol and its metabolites, and their application to direct serum injection assays.
Publication date: 1999
Alternative URL: http://pubs.rsc.org/en/Content/Database/AWB6111G00099
Abstract: With methacrylic acid and ethylene glycol dimethacrylate as function monomer and crosslinker, respectively, uniformly-sized molecularly imprinted polymers for (S)-propranolol (I) and propranolol (II) were prepared by polymerization (details available). These polymers were also selectively surface-modified with hydrophilic polymers using a 1:1 mixture of glycerol (di- and) monomethacrylates. Results indicated that (i) I-imprinted polymers showed enantioselectivity towards II and its metabolites; and (ii)-surface modified, II-imprinted polymers could be applied to direct serum injection assay of II and its metabolites. (Analytical Abstracts 1999)
Template and target information: propranolol, S-propranolol
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