MIPdatabase
Authors: Pernites R, Ponnapati R, Felipe MJ, Advincula R
Article Title: Electropolymerization molecularly imprinted polymer (E-MIP) SPR sensing of drug molecules: Pre-polymerization complexed terthiophene and carbazole electroactive monomers.
Publication date: 2011
Journal: Biosensors and Bioelectronics
Volume: 26
Issue: (5)
Page numbers: 2766-2771.
DOI: 10.1016/j.bios.2010.10.027
Alternative URL: http://www.sciencedirect.com/science/article/B6TFC-5192134-4/2/d87299153575c0265f782f7bffc08581
Abstract: A novel chemosensitive ultrathin film with high selectivity was developed for the detection of naproxen, paracetamol, and theophylline using non-covalent electropolymerized molecular imprinted polymers (E-MIP). A series of monofunctional and bifunctional H-bonding terthiophene and carbazole monomers were compared for imprinting these drugs without the use of a separate cross-linker. A key step is the fast and efficient potentiostatic method of washing the template, which facilitated enhanced real-time sensing by surface plasmon resonance (SPR) spectroscopy. Various surface characterizations (contact angle, ellipsometry, XPS, AFM) of the E-MIP film verified the templating and release of the drug from the cross-linked conducting polymer film
Template and target information: naproxen, paracetamol, theophylline
Author keywords: MIP, electropolymerization, Surface plasmon resonance (SPR) sensing, naproxen, paracetamol, theophylline
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