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Reference type: Journal
Authors: Barrios CA, Zhenhe C, Navarro-Villoslada F, López-Romero D, Moreno-Bondi MC
Article Title: Molecularly imprinted polymer diffraction grating as label-free optical bio(mimetic)sensor.
Publication date: 2011
Journal: Biosensors and Bioelectronics
Volume: 26
Issue: (5)
Page numbers: 2801-2804.
DOI: 10.1016/j.bios.2010.11.009
Alternative URL: http://www.sciencedirect.com/science/article/B6TFC-51G9BVW-6/2/3d800394631808c71377a9b9d754f330

Abstract: Micropatterned molecularly imprinted polymer (MIP) transmissive 2D diffraction gratings (DGs) are fabricated and evaluated as label-free antibiotic bio(mimetic)sensors. Polymeric gratings are prepared by using microtransfer molding based on SiO2/Si molds. The morphology of the MIP gratings is studied by optical and atomic force microscopes. MIP 2D-DGs exhibit 2D optical diffraction patterns, and measurement of changes in diffraction efficiency is used as sensor response. The refractive index of the micropatterned MIP material was estimated, via solvent index matching experiments, to be 1.486. Immersion of a MIP 2D-DG in different solutions of target-antibiotic enrofloxacin leads to significant variations in diffraction efficiency, demonstrating target-molecule detection. On the other hand, no significant response is observed for both control experiments: MIP grating exposed to a non-retained analyte and an equivalent non-imprinted polymer grating exposed to the target analyte, showing highly specific antibiotic label-free optical recognition
Template and target information: enrofloxacin
Author keywords: Optical sensor, molecularly imprinted polymer, Diffraction grating, Label-free sensing


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