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Proceedings title: Advanced Materials Research
Editors: Zhang GJ, Xu J
Publisher: Scientific.net
ISBN: ISSN: 10226680 ISBN: 978-087849216-9
Volume number: 160-162
Conference information: Materials Science and Engineering Applications

Abstract: Molecular imprinted polymer micrcosheres (MIPMs) were prepared through precipitation polymerization by andrographolide using as the template molecule. The morphologies of synthesized MIPMs were characterized by scanning electronmicroscope (SEM). Systematic investigations of the influences of key synthetic conditions, including functional monomers, cross-linkers and porogens, on the morphologies, yields and the recognition properties of the MIPs were conducted. The results indicated that the morphologies of MIPs with DVB as cross-linker was perfect, but their binding affinity is lower than that of MIPs with TRIM or EDMA as cross-linkers. And particle size of MIPs with TRIM as cross-linkers is small but with high binding affinity. Scatchard analysis revealed that the homogeneous binding sites were formed in the polymers. The application of MIPs with high affinity and excellent stereo-selectivity toward andrographolide in solid-phase extraction (SPE) column might offer a novel method for the enrichment and determination of terpenoids compounds in the traditional herbal medicine
Template and target information: andrographolide
Author keywords: Affinity properties, Andrographolide, Molecularly imprinted polymer microspheres, precipitation polymerization