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Abstract: The chromatographic behaviors of sulfachloropyridazine (SCP) and sulfadiazine (SDA) have been studied by HPLC with molecularly imprinted polymer (MIP) as the stationary phases. Molecularly imprinted polymer with SCP as template and an aqueous sodium dihydrogenphosphate buffer solution/acetonitrile (3:2, v/v) as mobile phase were found to be the best chromatographic system for achieving important separations of SCP and SDA from their mixtures. In order to compare the chromatographic data from the stationary phase, separation factors (a) were given. The values of a were 1.86 and 1.67 showed that the MIPs were able to recognize structurally subtle differences from the template molecule. The binding results from SCP and SDA solution performed by SCP-MIP showed specific binding towards SCP rather than SDA on the host-guest system. The values of capacity factor for SCP were measured and experimental results were further used for simulation to obtain the binding isotherms. The principal advantage of this method is that SCP-MIP can recognize SCP and SDA.
Template and target information: sulfachloropyridazine, SCP, sulfadiazine, SDA, sulfa drugs
Author keywords: molecularly imprinted polymer, high performance liquid chromatography, Sulfachloropyridazine (SCP), Sulfadiazine (SDA)