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Reference type: Journal
Authors: Najafi M, Mehdipour R
Article Title: Molecularly imprinted polymer-based potentiometric sensor for 2-aminopyridine as a potential impurity in piroxicam.
Publication date: 2011
Journal: Drug Testing and Analysis
Volume: 3
Issue: (2)
Page numbers: 132-137.
DOI: 10.1002/dta.207

Abstract: Abstract: A molecularly imprinted polymer-based potentiometric sensor was fabricated for determination of 2-aminopyridine (2-AP). The electroactive component is the 2-APH+. To form this specie the determination is carried out in a bufferic solution at pH 4.5 in which 2-AP is prevalently monoprotonated. Under these conditions, the membrane potential, increases with 2-AP concentration over a wide range of concentration (5 μM to 100 mM) with a near Nernstian response of 54.1 mV/decade and detection limit of 2.0 μM. The response time is less than 5 s and the sensor can be used for more than 3 months without any significant divergence in response. The selectivity coefficients of the proposed sensor were evaluated and exhibited good selectivity to 2-AP with respect to the electrode based on a non-imprinted polymer. The utility of the sensor was successfully tested by examining of 2-AP in piroxicam (PX) as a potential impurity. Copyright 2010 John Wiley & Sons, Ltd
Template and target information: 2-aminopyridine, 2-AP
Author keywords: Molecularly imprinted polymers, potentiometric sensor, 2-aminopyridine, Piroxicam


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