MIPdatabase
Authors: Yang HA, Guo TY, Zhou DZ
Article Title: Surface hydrophilic modification with well-defined glycopolymer for protein imprinting matrix.
Publication date: 2011
Journal: International Journal of Biological Macromolecules
Volume: 48
Issue: (3)
Page numbers: 432-438.
DOI: 10.1016/j.ijbiomac.2011.01.002
Alternative URL: http://www.sciencedirect.com/science/article/B6T7J-51Y57PC-2/2/83ec8a77fb0301f7a62bf6149caf80b7
Abstract: Well-defined lactose-containing glycopolymer has been synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization with (4-cyanopentanoic acid)-4- dithiobenozoate (CAD) as chain transfer agent. The glycopolymer was introduced onto the exterior surfaces of the bovine serum albumin (BSA) imprinted polymer beads by grafting copolymerization with methyl methacrylate and ethylene glycol dimethacrylate. After alcoholysis, the hydrophilic lactose residues of glycopolymer will stretched on the surface of the MIP beads and then the hydrophilicity of the surface will be enhanced. Rebinding test shows that the glycopolymer hydrophilic modified BSA imprinted polymer presents higher performance selectivity than that of unmodified one, which means that the hydrophobic-hydrophilic balance of the imprinted polymer surface is in favor of the improvement of specific recognition property of the material
Template and target information: protein, bovine serum albumin, BSA
Author keywords: protein imprinting, Glycopolymer, Hydrophilic modification
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