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Reference type: Journal
Authors: Meggers E
Article Title: From Conventional to Unusual Enyzme Inhibitor Scaffolds: The Quest for Target Specificity.
Publication date: 2011
Journal: Angewandte Chemie International Edition
Volume: 50
Issue: (11)
Page numbers: 2442-2448.
DOI: 10.1002/anie.201005673

Abstract: Abstract: The tremendous challenge presented by the specific molecular recognition of single biomacromolecular targets within complex biological systems demands novel and creative design strategies. This Minireview discusses some conventional and unusual approaches for the design of target-selective enzyme inhibitors with a focus on the underlying chemical scaffolds. These include complicated natural-product-like organic molecules, stable octahedral metal complexes, fullerenes, carboranes, polymetallic clusters, and even polymers. Thus the whole repertoire of organic, inorganic, and macromolecular chemistry can be applied to tackle the problem of target-specific enzyme inhibition
Template and target information: Review - Enzyme inhibitors
Author keywords: chemical biology, drug design, enzyme inhibitors, medicinal chemistry, selectivity


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