MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Rodríguez E, Navarro-Villoslada F, Benito-Peña E, Marazuela MD, Moreno-Bondi MC
Article Title: Multiresidue Determination of Ultratrace Levels of Fluoroquinolone Antimicrobials in Drinking and Aquaculture Water Samples by Automated Online Molecularly Imprinted Solid Phase Extraction and Liquid Chromatography.
Publication date: 2011
Journal: Analytical Chemistry
Volume: 83
Issue: (6)
Page numbers: 2046-2055.
DOI: 10.1021/ac102839n

Abstract: The present work describes the development of a sensitive and highly selective innovative method for the simultaneous detection of six fluoroquinolone (FQ) antimicrobials (enrofloxacin, ciprofloxacin, norfloxacin, levofloxacin, danofloxacin, and sarafloxacin) in water samples. This detection is based on online solid phase extraction, coupled to liquid chromatography (LC), using for the first time tailor-made molecularly imprinted microspherical polymer particles prepared via precipitation polymerization. Various parameters affecting the extraction efficiency of the polymer have been optimized to reduce nonspecific interactions and to achieve selective uptake of the antibiotics from real samples. The method shows good recoveries ranging between 62% and 102% (V = 25 mL) for the different FQs tested and excellent interday and intraday precision with relative standard deviation (RSD) values between 2 - 5% and 2 - 6%, respectively. The detection limits were between 1 - 11 ng L -1 (drinking water) and 1 - 12 ng L -1 (fish farm water) when 25 mL samples were processed. The polymer showed selectivity for FQs containing a piperazine moiety whereas no retention was found for other antibiotics or nonrelated compounds. The method has been applied to the analysis of trace amounts of the FQs tested in drinking and fish farm water samples with excellent recoveries (>91%) and good precision (RSDs <5%)
Template and target information: fluoroquinolone antimicrobials, FQs, enrofloxacin, ciprofloxacin, norfloxacin, levofloxacin, danofloxacin, sarafloxacin, NOR, LEVO, CIPRO, DANO, ENRO, SARA


  mipdatabase.com logo special offer joke shirt  Mug featuring the name Elena spelled out in the single letter amino acid code  HE-MAN polymer chemistry shirt

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner