MIPdatabase
Authors: Schwarz LJ, Danylec B, Harris SJ, Boysen RI, Hearn MTW
Article Title: Preparation of molecularly imprinted polymers for the selective recognition of the bioactive polyphenol, (E)-resveratrol.
Publication date: 2011
Journal: Journal of Chromatography A
Volume: 1218
Issue: (16)
Page numbers: 2189-2195.
DOI: 10.1016/j.chroma.2011.02.043
Alternative URL: http://www.sciencedirect.com/science/article/B6TG8-527PRN2-1/2/0ee5c9019580536c07bbe6a5710e99a2
Abstract: (E)-Resveratrol imprinted polymers have been rationally designed with the aid of molecular modelling and NMR spectroscopic titration techniques to determine the optimal ratio of the template to functional monomer for polymer formation. Based on this approach, (E)-resveratrol imprinted polymers were prepared via non-covalent self-assembly with the functional monomer 4-vinylpyridine (4VP) in a 1:3 molar ratio. Polymerisation in the presence of a cross-linker resulted in rigid block copolymers that had selective capacities towards (E)-resveratrol (e.g. 14 μmol/g) when compared to the non-imprinted reference polymer. The selectivity of these MIPs was also examined using several structurally related polyphenolic compounds to determine the influence of polyphenolic hydroxyl number and position on binding and molecular recognition
Template and target information: (E)-Resveratrol, Resveratrol
Author keywords: resveratrol, Polyphenols, solid phase extraction, molecular modelling, Molecularly imprinted polymers
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