Authors: Rosengren AM
, Karlsson BCG
, Näslund I
, Andersson PO
, Nicholls IA
In situ detection of warfarin using time-correlated single-photon counting.
Publication date: 2011
Journal: Biochemical and Biophysical Research Communications
Alternative URL: http://www.sciencedirect.com/science/article/B6WBK-5281SGG-6/2/933465c5a224d197ef6f4c846c664587
Abstract: Here we report on a novel method for the direct in situ measurement of specific isomeric forms of the anticoagulant warfarin using time correlated single-photon counting (TCSPC) spectroscopy in conjunction with synthetic Sudlow I binding site receptors. The method is highly robust over the clinically significant concentration range, and demonstrates the potential of the binding site mimics in conjunction with the spectroscopic strategy employed here for the determination of this important pharmaceutical in clinical or even environmental samples
Template and target information: warfarin
Author keywords: Warfarin, Time resolved fluorescence spectroscopy, Time correlated single photon counting, human serum albumin, Sudlow I, molecularly imprinted polymer, MIP
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