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Authors: Mizutani N, Yang DH, Selyanchyn R, Korposh S, Lee SW, Kunitake T
Article Title: Remarkable enantioselectivity of molecularly imprinted TiO2 nano-thin films.
Publication date: 2011
Journal: Analytica Chimica Acta
Volume: 694
Issue: (1-2)
Page numbers: 142-150.
DOI: 10.1016/j.aca.2011.02.042
Alternative URL: http://www.sciencedirect.com/science/article/B6TF4-52D51JW-1/2/83d96c85f02b9dfadd5d035166cc871e
Abstract: TiO2 nano-thin films with imprinted (R)- and (S)-enantiomers of propranolol, 1,1'-bi-naphthol, and 2-(4-isobutylphenyl)-propionic acid were fabricated on quartz plates by spin-coating their solutions with Ti(O-nBu)4 in a toluene-ethanol mixture (1:1, v/v). After template removal, the imprinted films showed better binding for original templates than to the corresponding enantiomers. The assessment of template incorporation, template removal, and re-binding was conducted through UV-vis measurements. Significant enhancement of enantioselectivity was achieved by optimization of the film thickness and by heat-treatment of the imprinted films. After subtraction of non-specific binding, the optimized films provided chiral recognition with the enantioselectivity of almost 100% for (R)-propranolol and 95% for (S)-propranolol
Template and target information: propranolol, 1,1'-bi-naphthol, 2-(4-isobutylphenyl)-propionic acid
Author keywords: molecular imprinting, surface sol-gel process, TiO2 gel films, enantiomer, chiral discrimination
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