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Reference type: Journal
Authors: Jiang JB, Song KS, Chen Z, Zhou Q, Tang YW, Gu FL, Zuo XJ, Xu ZG
Article Title: Novel molecularly imprinted microsphere using a single chiral monomer and chirality-matching (S)-ketoprofen template.
Publication date: 2011
Journal: Journal of Chromatography A
Volume: 1218
Issue: (24)
Page numbers: 3763-3770.
DOI: 10.1016/j.chroma.2011.04.043
Alternative URL: http://www.sciencedirect.com/science/article/pii/S002196731100553X

Abstract: We designed and synthesized a cinchonine derivative to be used as a novel chiral monomer. It was employed in a dual role of functional monomer and cross-linking monomer, displaying multi-binding sites for the template (S)-ketoprofen. Monodisperse molecularly imprinted core-shell microspheres were prepared using surface imprinting method on silica gel. The results show a substantial synergistic effect in the enantioselective recognition, confirming our initial hypothesis. Computational simulation of the monomer and template pre-arrangement strongly supports our proposed chiral recognition mechanism for the imprinted microspheres
Template and target information: (S)-ketoprofen
Author keywords: Surface molecular imprinting technique, Synergistic effect, enantiomer separation, ketoprofen, high-performance liquid chromatography, Computational simulation


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