MIPs logo MIPdatabase      MIP2024 Conference banner, website is now open, register on site for important updates   
Custom Search
Reference type: Journal
Authors: Jiang JB, Song KS, Chen Z, Zhou Q, Tang YW, Gu FL, Zuo XJ, Xu ZG
Article Title: Novel molecularly imprinted microsphere using a single chiral monomer and chirality-matching (S)-ketoprofen template.
Publication date: 2011
Journal: Journal of Chromatography A
Volume: 1218
Issue: (24)
Page numbers: 3763-3770.
DOI: 10.1016/j.chroma.2011.04.043
Alternative URL: http://www.sciencedirect.com/science/article/pii/S002196731100553X

Abstract: We designed and synthesized a cinchonine derivative to be used as a novel chiral monomer. It was employed in a dual role of functional monomer and cross-linking monomer, displaying multi-binding sites for the template (S)-ketoprofen. Monodisperse molecularly imprinted core-shell microspheres were prepared using surface imprinting method on silica gel. The results show a substantial synergistic effect in the enantioselective recognition, confirming our initial hypothesis. Computational simulation of the monomer and template pre-arrangement strongly supports our proposed chiral recognition mechanism for the imprinted microspheres
Template and target information: (S)-ketoprofen
Author keywords: Surface molecular imprinting technique, Synergistic effect, enantiomer separation, ketoprofen, high-performance liquid chromatography, Computational simulation


  SMI logo mug  Mother Periodic table shirt  Lab Chick script shirt






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner