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Reference type: Journal
Authors: Ding MJ, Wu XL, Yuan LH, Wang S, Li Y, Wang RY, Wen TT, Du SH, Zhou XM
Article Title: Synthesis of core-shell magnetic molecularly imprinted polymers and detection of sildenafil and vardenafil in herbal dietary supplements.
Publication date: 2011
Journal: Journal of Hazardous Materials
Volume: 191
Issue: (1-3)
Page numbers: 177-183.
DOI: 10.1016/j.jhazmat.2011.04.058
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0304389411004961

Abstract: An analytical procedure for selective extraction of sildenafil and vardenafil in herbal dietary supplements (HDSs) has been set up by using the magnetic molecularly imprinted polymers (MMIPs) as the extraction and clean-up materials, followed by high performance liquid chromatography-ultraviolet (HPLC-UV). The MMIPs were prepared by a surface molecular imprinting technique, using Fe3O4 magnetite as a magnetically susceptible component, sildenafil as template molecule, 2-(trifluoromethyl) acrylic acid (TFMAA) as functional monomer, ethylene glycol dimethacrylate (EGDMA) as polymeric matrix components. The MMIPs were characterized by transmission electron microscope (TEM), Fourier transform infrared spectrometer (FT-IR), X-ray diffraction (XRD) and vibrating sample magnetometer (VSM), respectively. The heterogeneity of the MMIPs was modeled with the Freundlich isotherm equation. The resulting MMIPs had high recognition ability and fast binding kinetics for sildenafil. The MMIPs were used as dispersive solid-phase extraction (DSPE) materials to selectively extract sildenafil and vardenafil from HDSs, the contents of sildenafil and vardenafil were found to be 8.05 and 3.86 μg g-1, respectively, and the average recoveries in spiked HDSs were 70.91-91.75% with a relative standard deviation (R.S.D.) below 7%. The MMIPs were successfully used to selectively enrich and determine sildenafil and vardenafil from HDSs
Template and target information: sildenafil, vardenafil, PDE-5 inhibitors, Viagra, Levitra
Author keywords: Magnetic molecularly imprinted polymers, PDE-5 inhibitors, Sildenafil, Herbal dietary supplements, HPLC-UV


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