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Abstract: Chiral sensing in organic solvent by the gate effect of a molecularly imprinted polymer (MIP) was attempted in this work. We grafted poly-(methacrylic acid-co-ethyleneglycol dimethacrylate)imprinted by D- or L-phenylalanine anilide (PAA)or nothing on indium-tin oxide (ITO) electrode. The electrode is termed D- or L-MIP-ITO or Blank-ITO, respectively. Cyclic voltammetry of ferrocene in dichloromethane was performed with the treated electrode. The effect of the presence of D- or L-PAA in the current were observed. As the results. the anodic current at the D- or L-MIP-ITO decreased (more than 10 %) by its template of 5 mM. However it was hardly sensitive to the 5 mM enantiomer of the template. The current of the Blank-ITO was insensitive to either of the PAA. Those results show that this gate effect would be potentially applicable for simple amperometric sensors with enantio-selectivity. The sensor can work in organic solvent, which is a remarkable advantage comparing with biosensors using enzymes or antibodies. (author abst.)
Template and target information: phenylalanine anilide, PAA