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Conference information: Abstracts, 15th Iranian Chemistry Congress

Abstract: Molecular imprinting, first constructed by Wulff [1] and Mosbach [2], is a method for making artificial binding sites in a polymer. MIPs are facile technique and typically prepared by polymerizing a combination of a target molecule (template), functional monomers and an excess of cross-linker. Binding sites with molecular recognition properties are formed after removing template molecules from the polymerized network, leaving behind cavities complementary in size and shape to the template for the subsequent rebinding process. However, diffusion of the analyte across the MIP and heterogeneous distribution of the binding sites are the most problem with use of MIPs prepared by conventional methods. Therefore, MIPs need to modify in order to attain a rapid response and reduce binding time. MWCNTs could be convenient option as a support material to overcome above problems that encountered with use of the MIPs. Herein, a sensitive electrochemical sensor was fabricated for allopurinol (AP) based on molecularly imprinted polymer (MIP) immobilized on multiwall carbon nanotube (MWCNT) surface. Thin film of MIP immobilized on MWCNT surface (MIPCNT) with specific binding sites for AP was cast on glassy carbon electrode (GCE). The morphology and features of the MIPCNT film was characterized by field emission scanning electron microscopy (FE-SEM), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and amperometric measurements (I–t) in detail. The adsorbed amount of AP approached the equilibrium value upon 9 min adsorption. The modified electrode was used to detect the concentration of AP with a linear range and detection limit (S/N=3) of 1.0-0.01 μM and 6.88 nM, respectively. The MIPCNT film displayed excellent selectivity towards AP. Finally, the modified electrode was successfully applied to determination of AP in the human serum sample and two brand tablet samples
Template and target information: allopurinol