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Conference information: Abstracts, 15th Iranian Chemistry Congress

Abstract: Drug abuse has increased dramatically during the past three decades. Ephedrine has been characterized as a prohibited compound by the International Olympic Committee [1]. Athletes tested positive for ephedrine often claim to have received it while using products without indication, due to the fact that ephedrine is an ingredient of common anti-cold preparations and of various nutritional supplements. Therefore, the determination of ephedrine in biological and pharmaceutical samples via a simple, fast, inexpensive, reliable and sensitive method is of great interest. The different procedures developed for the detection and determination of ephedrine in plasma and urine such as gas-liquid chromatography, radioimmunoassay, membrane electrode methods, liquid chromatography and capillary electrophoresis involve laborious, intensive, and expensive procedures [2]. The capacitive sensing method has attracted considerable attention in modern analytical chemistry because of their sensitivities and specificities. Moreover it provides simple and inexpensive detection of analyte–receptor binding without using additional reagents or labels. Capacitance transducer is based on the electrical double layer theory. Any adsorption or binding of reagents onto the dielectric layer changes its thickness and/or dielectric behavior, which can be detected by measuring the capacitance of the system [3]. In this study, we developed a capacitive chemical sensor based on an electropolymerized molecularly imprinted polymer for ephedrine detection. Electrochemical impedance spectroscopy was applied for rapid and sensitive estimation of ephedrine levels. The sensor´s linear response range was between 1-15 μM, with a detection limit of 0.4 μM. selectivity and reproducibility and repeatability of the sensor were all found to be satisfactory
Template and target information: ephedrine