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Reference type: Conference Proceeding
Authors: Tamaddona A, Karimkhania L, Keyvanfara S, Akbari-Adergani B
Publication date: 2011
Article title: Synthesis of molecularly imprinted polymer as sorbent for selective extraction of olanzapine.
Alternative URL: http://icc2011.ir/Docs/D.pdf

Conference information: Abstracts, 15th Iranian Chemistry Congress

Abstract: Olanzapine is one of the most commonly used drugs for atypical antipsychotics. Olanzapine has been approved by the FDA for the treatment of schizophrenia, acute mania in bipolar disorder, agitation associated with schizophrenia and bipolar disorder, and as maintenance treatment in bipolar disorder and psychotic depression. In this study, a novel method is described for the determination of olanzapine using molecularly imprinted solid-phase extraction (MISPE) combined with high-performance liquid chromatography (HPLC). The water-compatible molecularly imprinted polymers (MIPs) were prepared using methacrylic acid as functional monomer, ethylene glycol dimethacrylate (EGDMA) as cross-linker, 2,2-Azobis(isobutyronitrile) or AIBN as a commonly used initiator with the presence of chloroform as porogen solvent and olanzapine as template molecule. The novel imprinted polymer was used as a sorbent for the extraction and determination of olanzapine in pharmaceuticals. Various parameters affecting the extraction efficiency of the polymer have been evaluated. The MIP selectivity was evaluated by checking substances with similar molecular structures to that of olanzapine
Template and target information: olanzapine


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