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Conference information: Abstracts, 15th Iranian Chemistry Congress

Abstract: In the past decades, modern sample preparation methods such as solid-phase micro-extraction (SPME), membrane-assisted solvent extraction (MASE) and stir-bar sorptive extraction (SBSE) [1] have been developed. In recent years, inside-needle capillary adsorption trap (INCAT) technique has been developed as a solvent-free sample preparation approach [2]. Molecular imprinting polymer (MIP) is a technology to produce polymers programmed to recognize a target or a class of target molecules [3]. A novel inside-needle extraction method was developed through thermal polymerization of methamphetamine (MAMP)-MIP on the interior surface of a 1 mm i.d. stainless steel tube. 1.9 mmol MAMP and 30 mmol methacrylic acid were dissolved in 30 mL acetonitrile (porogen). Then, 120 mmol ethylene glycol dimethacrylate and 280 mg of AIBN (initiator) were added. The stainless steel tube with a flexible steel wire (10cm × 0.2mm o.d.) in the middle was filled with the prepared pre-polymer solution and was sealed with septum. The polymerization was carried out at 50°C for 14 h. After completion of the polymerization, the wire was withdrawn. The coated stainless steel tube could be mounted on a glass syringe and used as an extraction device (extraction needle). It was directly coupled with GC systems. The parameters being effective on extraction processes, namely sample volume, flow rate, pH and ionic strength of the sample were investigated and optimized. The fabricated needle coating (MAMP-MIP layer) was durable and showed very good chemical and thermal stability. The extraction needle showed high selectivity as well as great extraction capacity for MAMP. The extraction of MAMP, amphetamine (AMP) and 3,4- methylenedioxymethamphetamine (MDMA, Ecstasy) was performed using the fabricated extraction needle followed by GC analysis. The fabricated needle was proved to be applicable to the analysis of real samples by comparing the results obtained for non-spiked and spiked samples of urine
Template and target information: methamphetamine, MAMP, amphetamine, AMP, 3,4-methylenedioxymethamphetamine, MDMA, Ecstasy