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Conference information: Abstracts, 15th Iranian Chemistry Congress

Abstract: Molecular imprinting is a rapidly growing field relevant to science research as well as industrial applications related to separation, artificial receptors, catalysts, and sensors, since molecularly imprinted polymers (MIPs) have high selectivity, mechanical strength, and resistance to acids, bases, organic solvents, high pressures, and temperatures. Molecular imprinting forms selective recognition sites that are complementary both in shape and chemical structure to the template molecule, and after removal of the template, these sites can bind to the template molecule or closely related structural analogues with similar affinity and selectivity as natural antibodies. Additionally, MIPs are stable, easy to prepare, inexpensive, and can be reused many times without decrease in performance [1,2,3]. In this study, a novel method is described for the determination of ethambutol (EMB) in aqueous solution using molecularly imprinted solid-phase extraction as the sample clean-up technique combined with UV detection at 262 nm, using acetic acid/sodium acetate buffer solution (pH:5) containing copper(II) sulphate to form the ethambutol–copper(II) complex. Under the optimum conditions, the calibration graph was linear at the concentration range 5-200 mgL -1 of ethambutol. The molecularly imprinted polymer (MIP) was prepared using methacrylic acid as functional monomer, ethylene glycol dimethacrylate as cross-linker, tetrahydrofuran as porogen and ethambutol as template molecule. In result, high recovery (>80%) of EMB was achieved.Various parameters affecting the extraction efficiency of the polymer and optimal conditions for the MIP cartridges and MIP selectivity are evaluated by checking several substances with similar molecular structures to ethambutol. As a control, the nonimprinted polymer (NIP) in the absence of the template was prepared and treated by using the same method
Template and target information: ethambutol, EMB