Abstract: The controlled release system of MIP-Asp hydrogel was prepared by using self-assembly molecular imprinted technique (MIP). 1H NMR was used to detect the changes of active hydrogen atoms. Moreover, the effect of crosslinking degree of hydrogel on the release of medicine was investigated and the temperature/pH sensitivity was also considered. The results demonstrated that: the MIPs-Asp was a procedure involving the participation of active hydrogen; the lower crosslinking degree corresponded to the higher medicine release ratio; high temperature is better for the release; weak acidity is better for the release of Asp.
Template and target information: aspirin, acetylsalicylic acid
Author keywords: Aspirin, 1H NMR, MIPs