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Reference type: Conference Proceeding
Authors: Chu HJ, Wei HL, Zhu J, Nong CP
Publication date: 2011
Article title: Synthesis and Performance of Molecular Imprinted Polymers as Drug Release Controller.
Page numbers: 446-449
DOI: 10.4028/www.scientific.net/AMM.130-134.446 Alternative URL: http://www.scientific.net/AMM.130-134.446

Proceedings title: Applied Mechanics and Materials
Editors: Zhao H
Publisher: Trans Tech Publications
City: Switzerland
Volume number: 130-134
Conference information: Mechanical and Electronics Engineering III

Abstract: Molecular imprinted polymers were synthesized using α-methylacrylacid as monomer, acetylsalicylic acid as template. Polyethylene glycol dimethylacrylate was taken as cross-linker. UV-Vis spectrophotometer was used to detect the drug-loading and releasing performances of these polymers. The studies showed that the imprinted polymers could load more drugs than non-imprinted polymer, and exhibited a slower drug-releasing rate than the latter at pH 7.4. The content of cross-linker had influences on drug-loading amounts. The imprinted polymer released few drugs at the buffer solution of pH 1.2.
Template and target information: acetylsalicylic acid, aspirin
Author keywords: cross-linker, Drug release, functional monomer, molecular imprinted polymer, template


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