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Reference type: Journal
Authors: White CJ, Tieppo A, Byrne ME
Article Title: Controlled drug release from contact lenses: a comprehensive review from 1965-present.
Publication date: 2011
Journal: Journal of Drug Delivery Science and Technology
Volume: 21
Issue: (5)
Page numbers: 369-384.

Abstract: This review covers the progress within the field of drug releasing contact lenses since 1965. It highlights the enormous potential of controlled release mechanisms and offers a comprehensive, comparative review of lenses, drugs, methods, drug loading, drug deliver), rate, and release duration. Methods have included molecular imprinting as well various forms of mediated release via carriers, surfactants, inclusion complexes, and molecular barriers. Drug-soaked lens were the earliest releasing lenses, but they offer very little control over the release profile with low drug loading, are characterized by decaying, Fickian release rates, and typically reach completion in a very short amount of time. Molecular imprinting is consistently one of the most promising and versatile methods of enhanced drug loading and extended release with tailorable control over release rate when factors are balanced such Os lens thickness, material, and release media and conditions.
Template and target information: Review - Controlled release from contact lenses
Author keywords: Drug-eluting contact lenses, Controlled ocular drug delivery, therapeutic contact lenses, Drug-soaked lenses, molecular imprinting


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