MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Huang MX, Pang WS, Zhang J, Lin SD, Hu J
Article Title: A target analogue imprinted polymer for the recognition of antiplatelet active ingredients in Radix Salviae Miltiorrhizae by LC/MS/MS.
Publication date: 2012
Journal: Journal of Pharmaceutical and Biomedical Analysis
Volume: 58
Issue: (1)
Page numbers: 12-18.
DOI: 10.1016/j.jpba.2011.09.010
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0731708511005280

Abstract: The purpose of this study was to prepare a propyl gallate (PrG) molecular imprinted polymer as a cartridge stuffing material to isolate antiplatelet active ingredients. A macroporous polymer was synthesized utilizing ethylene glycol dimethacrylate (EDMA) as the crosslinking agent, PrG as the template molecule and 4-vinylpyridine (4-Vpy) as the functional monomer. Subsequently, PrG was removed by washing with methanol-glacial acetic acid (9:1, v/v). The molecular imprinted polymer recognized an active ingredient, protocatechuic acid, from a crude extract of the Chinese herbal medicine, Radix Salviae Miltiorrhizae (Danshen), using an on-line column switching solid phase extraction process. Pharmacological experiments showed that protocatechuic acid inhibits arachidonic acid (10 mg/kg) induced aggregation of rat platelets in vivo. This study provides an example of an application of separation-analysis technique for screening potentially bioactive compounds
Template and target information: propyl gallate, PrG, antiplatelet active ingredients, protocatechuic acid
Author keywords: Propyl gallate, molecular imprinted polymer, On-line extraction, LC, MS, MS, Antiplatelet ingredient, Recognition


  Periodic table Teacher shirt  Imprinting peptide mug  Gravity waves shirt

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner